I thought it was funny and you have a lot of good stuff in there, but the jokes are overshadowed by the random organization which is overdone. A little out there, but funny. Try to make the content flow a little more instead of just one liners.
Why hasn't anyone written on Shrooms before? I have no idea. I think you have a good start, and with improvement it could be awesome. More content would be nice, as long as it's adding something new.
Prose and formatting:
Not a strong point. The conversation quickly gets way too random and stupid, even though there are some good lines in there. The pictures could be formatted better so it doesn't look like you slapped them all together. I like the overall feel, but it's hard to follow the storyline you're establishing.
Random, even though the article is on shrooms you should tie them in better to the context. Anything with a lot of different colors and a weird picture could make sense in an article about Shrooms, so choose them wisely.
The random theme could work, but there is a big difference between random and sloppy. Good start but I think you could do better!
This is my first review so feel free to criticize me or just hate me behind my back. :D