- Blue: Stimulants generally increase in potency to the upper left.
- Red: Depressants generally increase in potency to the lower right.
- Green: "Hallucinogens" are psychedelic to the left, dissociative to the right, generally less predictable down and to the right, and generally more potent towards the bottom.
- Pink hue: The so called "antipsychotics". A new and controversial addition to the chart.