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- Syphilis, "The Great Pox"
- Black Death, colloquially known as "The Pox."
- Pox, an abbreviation for Orthopox 13, a character from the game Destroy All Humans!
- Pox, a slang word for Acne
- Plain Old XML, a term used to describe basic XML, a computer data representation format
- President of Xanadu
- "Sea pox", what Dutch people call acorn barnacles, apparently.