Osmosis Jones is a 2001 American live-action/animated buddy cop comedy film with decent animated scenes directed by Tom Sito and Piet Kroon and horrendous live-action scenes directed by the Farrelly Brothers (though the commercials, end credits, and Amazon.com product descriptions outright lie to you and claim the Farrellys were the movie's "main" directors). It centers on Osmosis "Ozzy" Jones, an African-American white blood cell cop who complains that germs are trying to oppress him with viruses and infections, and Drix, a whitebread cold pill straight outta the FDA who is no match for Ozzy's utter hipness and spleenwise attitude. The two must break down the racial cell walls and prevent seductive virus Thrax from killing their host body — slovenly zookeeper and deadbeat dad Frank Detorre — within forty-eight hours. Ultimately, Jones is caught in an intimate triad, and must decide between his best friend Drix, Big Daddy Thrax, and Mayor Shatner's curvaceous secretary Leah.
Osmosis Jones was met with mixed reviews, with critics praising the fun and educational animated portions but criticizing the live-action portions, their degradation of national treasure Bill Murray, and their use of sub-Will Ferrell gross-out humor featuring exploding zits. The film was the second in a string of financial failures by Warner Bros. Feature Animation, hoping to find success at the antipode to The Iron Giant, though it certainly wouldn't be their last multi-million-dollar mistake as Warner continued to struggle with long-term illness and creative decisions indicative of degenerative brain damage from late-stage Rabbititis. (more...)